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Related Concept Videos

Assessment of Diffusion and Perfusion01:17

Assessment of Diffusion and Perfusion

Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this principle...

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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

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Published on: July 28, 2013

Disability in optic neuritis correlates with diffusion tensor-derived directional diffusivities.

R T Naismith1, J Xu, N T Tutlam

  • 1Department of Neurology, Washington University, Saint Louis, MO, USA. naismithr@neuro.wustl.edu

Neurology
|December 17, 2008
PubMed
Summary
This summary is machine-generated.

Diffusion tensor imaging (DTI) shows promise for predicting optic neuritis (ON) outcomes. Axial diffusivity changes in acute ON correlate with vision, while radial diffusivity in chronic ON relates to structural and functional vision tests.

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Area of Science:

  • Neuroimaging
  • Ophthalmology
  • Neurology

Background:

  • Optic neuritis (ON) is an inflammatory demyelinating disease of the optic nerve.
  • Predicting clinical outcomes in ON is crucial for patient management.
  • Diffusion tensor imaging (DTI) offers insights into tissue microstructure.

Purpose of the Study:

  • To evaluate directional diffusivities from DTI for predicting ON clinical outcomes.
  • To correlate DTI parameters with vision, optical coherence tomography (OCT), and visual evoked potentials (VEP).

Main Methods:

  • DTI data acquired at 3T in 12 acute ON cases, 28 remote ON cases, and 12 healthy controls.
  • Prospective follow-up for acute ON and cross-sectional study for remote ON.
  • Analysis of axial diffusivity, radial diffusivity, apparent diffusion coefficient (ADC), and fractional anisotropy (FA).

Main Results:

  • Acute ON showed a decrease in axial diffusivity, correlating with future contrast sensitivity.
  • In remote ON, radial diffusivity increased and correlated with OCT, contrast sensitivity, visual acuity, and VEP.
  • Diffusion parameters were dynamic, changing from acute to remote stages of ON.

Conclusions:

  • Axial diffusivity is a potential predictor of clinical outcomes in acute ON.
  • Diffusion parameters are dynamic and change throughout the course of ON.
  • Radial diffusivity in remote ON correlates with multiple measures of visual function and structure.