Related Experiment Video
Updated: Jun 27, 2026

Protein Target Prediction and Validation of Small Molecule Compound
Published on: February 23, 2024
Is Cdc25 a druggable target?
1Department of Pharmacology and Chemical Biology, Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15260, USA. lazo@pitt.edu
Abstract:
Proper control of cell cycle progression requires the functionality of a small family of activating phosphatases termed Cdc25, which have been implicated in cancer and Alzheimer's disease. These protein tyrosine phosphatases are therefore recognized as attractive molecular targets for small molecules. We review the rationale, approaches, progress and challenges for developing small molecule inhibitors of the Cdc25 family. A number of potential chemical probes are discussed and their characteristics are summarized.
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