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Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells
22:06

Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells

Published on: February 25, 2007

Hematopoietic stem cells: source matters

Richard L Haspel1, Kenneth B Miller

  • 1Deaconess Medical Center, Department of Pathology, 330 Brookline Avenue, Yamins 309, Boston, MA 02215, USA. rhaspel@bidmc.harvard.edu

Current Stem Cell Research & Therapy
|December 17, 2008
PubMed

Bone marrow, peripheral blood and cord blood are all sources of hematopoietic stem cells for allogeneic transplants. These sources differ in regard to collection methods, cellular content and transplant outcomes. In the related setting, use of peripheral blood stem cells, when compared to bone marrow, results in faster engraftment and may confer a survival benefit in advanced disease but also may lead to an increase in chronic graft-versus-host-disease. While cord blood stem cells are the simplest to collect and allow the greatest flexibility in HLA matching, they contain the lowest stem cell dose leading to the slowest engraftment. In this review, we discuss the advantages and disadvantages of these different stem cell sources as well as areas for further research.

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