Related Experiment Video
Updated: Jun 27, 2026
09:09
Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery
Published on: June 23, 2020
Engineered nanoparticles in cancer therapy
Natalie P Praetorius1, Tarun K Mandal
1College of Pharmacy, Xavier University of Louisiana, New Orleans, Louisiana 70125-1098, USA.
Recent Patents on Drug Delivery & Formulation
|December 17, 2008
Summary
Nanoparticle technology offers advanced cancer therapies by targeting tumors effectively and minimizing side effects. This review highlights recent patents on nanoparticles for improved cancer detection and treatment.
Area of Science:
- Oncology
- Nanotechnology
- Biomedical Engineering
Background:
- Cancer research has advanced understanding at genetic, molecular, and cellular levels.
- Nanoparticulate technology offers improved cancer therapies by overcoming biological barriers.
- Nanoparticles (1-100 nm) are engineered for targeted drug delivery and cancer treatment.
Purpose of the Study:
- To review recent patents on nanoparticle development for cancer detection and treatment.
- To highlight nanoparticle applications in enhancing antitumor efficacy and reducing side effects.
- To discuss the role of nanoparticles in overcoming biological and biophysical barriers.
Main Methods:
- Review of recent US and World patents related to cancer nanoparticles.
- Analysis of nanoparticle engineering for targeted delivery and therapeutic functions.
- Examination of nanoparticle applications in various cancer treatment modalities.
Main Results:
- Nanoparticles enable selective tumor access due to size and modifiability.
- Engineered nanoparticles exploit cancer morphology for targeted intervention.
- Nanoparticles facilitate drug delivery across barriers like the blood-brain barrier.
Conclusions:
- Nanoparticles are crucial for a new generation of targeted cancer therapies.
- Multifunctional nanoparticles can simultaneously deliver drugs and imaging agents.
- Recent patents demonstrate significant advancements in nanoparticle-based cancer diagnostics and therapeutics.
Related Concept Videos
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
02:50Combination Therapies and Personalized Medicine
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...