Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Oral Drug Delivery Systems: Delayed-Release Systems

Oral Drug Delivery Systems: Delayed-Release Systems

Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...

Modified-Release Drug Delivery Systems: Rate-Programmed I

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...

Modified-Release Drug Delivery Systems: Classification

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...

Oral Drug Delivery Systems: Continuous-Release Systems

Oral Drug Delivery Systems: Continuous-Release Systems

Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...

Modified-Release Drug Delivery Systems: Rate-Programmed II

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...

Modified-Release Drug Delivery Systems: Drug Release Characteristics

Modified-Release Drug Delivery Systems: Drug Release Characteristics

Drug release from modified-release dosage forms is designed to achieve specific therapeutic effects by controlling the rate and extent of drug release. The classification of these drug release systems is based on key pharmacokinetic assumptions: drug disposition follows first-order kinetics, drug release is the rate-limiting step in absorption, and the released drug is rapidly and completely absorbed.There are four major models of drug release patterns. The first model is the slow zero-order...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Ethnobotanical insights, antioxidant potential and cell line (RAW 264.7)-based anti-inflammatory activity of <i>cordia dichotoma</i> G. Forst fruits.

Journal of food science and technology·2026

Same author

Bioactive metabolites and antidiabetic activity of Cannabis sativa-derived endophytic fungi.

Archives of microbiology·2025

Same author

Biogenic Gold Nanocrystals Knock Down <i>Pseudomonas aeruginosa</i> Virulence via Quorum-Sensing and Antibiofilm Potential.

Nanomaterials (Basel, Switzerland)·2025

Same author

Biochemical profiling, anti-biofilm, and anti-quorum sensing activities of <i>Psophocarpus tetragonolobus</i> (L.) DC. root-tuber.

Natural product research·2025

Same author

Comprehensive analysis of micro and macro-minerals, phytochemicals and proximate composition of <i>Cordia dichotoma</i> G. forst fruits.

Journal of food science and technology·2024

Same author

Emerging advances in glycoengineering of carbohydrates/glycans and their industrial applications.

Biotechnology advances·2024

Same journal

Techniques of Mucilage and Gum Modification and their Effect on Hydrophilicity and Drug Release.

Recent patents on drug delivery & formulation·2020

Same journal

Oral Disintegrating Tablets - An Updated Patent Perspective.

Recent patents on drug delivery & formulation·2020

Same journal

Increasing Progenitor Cell Proliferation in the Sub-Ventricular Zone: A Therapeutic Treatment for Progressive Multiple Sclerosis?

Recent patents on drug delivery & formulation·2020

Same journal

Progresses and Challenges of Fast Dissolving/Disintegrating Dosage Forms in Manufacturing, Formulation Screening, Preclinical Testing and Drug Delivery.

Recent patents on drug delivery & formulation·2020

Same journal

Study and Development of an Anthroposophical Formula Based on <i>Phosphorus</i> and <i>Formica rufa</i> for Onychomycosis´s Treatment.

Recent patents on drug delivery & formulation·2020

Same journal

A Review on Recent Technologies and Patents on Silica Nanoparticles for Cancer Treatment and Diagnosis.

Recent patents on drug delivery & formulation·2020

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 27, 2026

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

Published on: August 9, 2022

Modified-release solid formulations for colonic delivery.

Brahma N Singh¹

¹Department of Formulation, Pharmaceutical Research & Development, Forest Laboratories, Inc., Commack, New York 11725, USA. brahmasingh@hotmail.com

Recent Patents on Drug Delivery & Formulation

|December 17, 2008

Summary

This summary is machine-generated.

Targeted colonic drug delivery systems offer localized treatment for GI diseases and improved bioavailability. Recent patents explore pH, microflora, time, and pressure-controlled modified-release (MR) formulations for effective colonic delivery.

More Related Videos

Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform

Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform

Published on: October 20, 2020

Bacterial Cellulose Spheres that Encapsulate Solid Materials

Bacterial Cellulose Spheres that Encapsulate Solid Materials

Published on: February 26, 2021

Related Experiment Videos

Last Updated: Jun 27, 2026

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

Published on: August 9, 2022

Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform

Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform

Published on: October 20, 2020

Bacterial Cellulose Spheres that Encapsulate Solid Materials

Bacterial Cellulose Spheres that Encapsulate Solid Materials

Published on: February 26, 2021

Area of Science:

Pharmaceutical Sciences
Drug Delivery Systems
Gastroenterology

Background:

Solid formulations for targeted lower gastrointestinal (GI) drug release aid localized treatment of inflammatory bowel diseases, irritable bowel syndrome, and colon cancer.
Colonic formulations can delay systemic absorption, enabling chronotherapy for circadian-affected diseases and enhancing bioavailability of poorly absorbed drugs like proteins and peptides.
Modified-release (MR) technologies are crucial for localized GI treatment and improved drug absorption.

Purpose of the Study:

To review recent patent literature on modified-release (MR) formulation technologies for colonic drug delivery.
To categorize these technologies based on the physiological characteristics of the colon they exploit.
To highlight promising approaches for targeted therapeutic molecule delivery to the colon.

Main Methods:

Review of recent patent literature on colonic drug delivery systems.
Classification of MR technologies based on colonic physiological triggers: pH, microflora, transit time, and luminal pressure.
Analysis of formulation strategies for targeted therapeutic molecule delivery.

Main Results:

Colonic delivery systems utilize colon's unique physiological characteristics: pH, microflora, transit time, and pressure.
MR technologies are grouped into four classes: pH-controlled, time-controlled, microbially-controlled, and pressure-controlled systems.
Formulations responding to colonic pH and/or enterobacteria are most prevalent and promising.

Conclusions:

Modified-release (MR) formulations offer advanced strategies for targeted colonic drug delivery.
pH-controlled and microbially-controlled systems are particularly effective and widely patented for colonic delivery.
These technologies hold significant potential for treating colonic diseases and improving drug efficacy.