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Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
Published on: September 20, 2017
Smart polymer based delivery systems for peptides and proteins
Khaled Al-Tahami1, Jagdish Singh
1Department of Pharmaceutical Sciences, College of Pharmacy, North Dakota State University, Fargo, ND 58105, USA.
Recent Patents on Drug Delivery & Formulation
|December 17, 2008
Summary
Smart polymers offer advanced biodegradable systems for delivering peptide and protein drugs. These in situ gel-forming polymers respond to stimuli, enhancing drug delivery with improved profiles and ease of use.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Drug Delivery Systems
Background:
- Biodegradable polymers are crucial for delivering bioactive agents like peptide and protein drugs.
- Advancements in pharmacology and mass production have increased the need for effective delivery systems.
- In situ gel-forming polymers offer advantages over conventional drug delivery methods.
Purpose of the Study:
- To review patented strategies for using smart polymers in peptide and protein drug delivery.
- To discuss the advantages, disadvantages, possibilities, and limitations of various smart polymer systems.
- To highlight the potential of stimuli-responsive polymers in biomedical applications.
Main Methods:
- Review of scientific literature and patent databases.
- Analysis of stimuli-responsive mechanisms (UV, pH, temperature, solvent exchange).
- Evaluation of polymer properties for drug encapsulation and release.
Main Results:
- Several patented strategies for smart polymer-based drug delivery have been developed.
- In situ gelation triggered by various stimuli allows for controlled drug release.
- These systems offer improved manufacturing, administration, and release profile modulation.
Conclusions:
- Smart, in situ gel-forming biodegradable polymers represent a significant advancement in peptide and protein drug delivery.
- These systems provide versatile and tunable platforms for various biomedical applications.
- Further research and development hold promise for overcoming existing limitations and expanding their clinical use.
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