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Updated: Jun 27, 2026
08:19
Solid Lipid Nanoparticles (SLNs) for Intracellular Targeting Applications
Published on: November 17, 2015
Recent developments and patenting of lipoprotein based formulations
András G Lackó1, Donald R Stewart, Robert McClain
1University of North Texas Health Science Center, Fort Worth, TX 76107, USA. alacko@ hsc.unt.edu
Recent Patents on Drug Delivery & Formulation
|December 17, 2008
Summary
Plasma lipoproteins offer innovative drug delivery solutions, especially for poorly soluble drugs. Patent activity highlights their potential for enhanced drug delivery and cancer chemotherapy applications.
Area of Science:
- Biochemistry
- Pharmacology
- Nanotechnology
Background:
- Drug discovery advances necessitate novel drug delivery systems.
- Poor drug solubility limits the efficacy of many formulations.
- Plasma lipoproteins are natural, biocompatible carriers for hydrophobic compounds.
Purpose of the Study:
- To review patenting activity in lipoprotein-based drug delivery systems.
- To highlight the potential of lipoproteins in cancer chemotherapy.
- To explore enhanced drug delivery strategies using lipoproteins.
Main Methods:
- Review of recent patent literature on lipoprotein formulations.
- Analysis of patents focusing on drug delivery applications.
- Examination of patents related to cancer chemotherapy using lipoproteins.
Main Results:
- Significant increase in patent filings for lipoprotein drug delivery vehicles.
- Lipoprotein formulations show promise for improving solubility and bioavailability.
- Receptor-mediated uptake mechanisms are key for targeted delivery, especially in cancer cells.
Conclusions:
- Lipoprotein-based drug delivery is a rapidly growing field with substantial patent activity.
- These systems offer a viable strategy for revitalizing failed drug formulations.
- Lipoproteins hold significant promise for targeted cancer chemotherapy.
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