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Orally disintegrating systems: innovations in formulation and technology
Honey Goel1, Parshuram Rai, Vikas Rana
1Pharmaceutics Division, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, India.
Recent Patents on Drug Delivery & Formulation
|December 17, 2008
Summary
Orally disintegrating systems offer improved patient compliance, especially for elderly and pediatric populations. This review discusses patents on formulation ingredients and technologies for these challenging dosage forms.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Formulation Technology
Background:
- Orally disintegrating systems enhance patient compliance, particularly for geriatric and pediatric groups.
- These systems are beneficial for patients with swallowing difficulties or conditions causing nausea and vomiting.
- They are suitable for drugs absorbed via oral mucosa or requiring rapid action.
Purpose of the Study:
- To review patents related to orally disintegrating systems.
- To discuss various formulation ingredients and manufacturing technologies for these systems.
- To address the challenges in achieving both mechanical strength and rapid disintegration.
Main Methods:
- Review of patents concerning orally disintegrating systems.
- Analysis of formulation ingredients and manufacturing techniques.
- Discussion of challenges and innovations in the field.
Main Results:
- Various dosage forms (tablets, films, nanoparticles) and manufacturing technologies (freeze-drying, melt extrusion) have been developed.
- Taste-masking techniques are crucial due to oral drug release.
- Balancing mechanical strength with rapid disintegration remains a key challenge.
Conclusions:
- Innovations in formulation and technology are essential for developing effective orally disintegrating systems.
- Understanding patent landscapes provides insights into advancements in this drug delivery field.
- Further research is needed to overcome the inherent challenges in creating ideal orally disintegrating dosage forms.
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