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Combining Single-molecule Manipulation and Imaging for the Study of Protein-DNA Interactions
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Interrogating single molecules.

Lin Cong1, Alexander D Wissner-Gross

  • 1Department of Physics, Harvard University, 17 Oxford Street, Cambridge, MA 02138, USA.

Recent Patents on Nanotechnology
|December 17, 2008
PubMed
Summary
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Advancements in nanotechnology require observing single molecules. Recent patents focus on instrumentation for fluorescence imaging, optical tweezers, and anti-Brownian traps to actively interrogate molecules in solution.

Area of Science:

  • Nanoscience and nanotechnology
  • Molecular imaging and manipulation

Background:

  • Nanotechnology development is contingent upon observing and probing at the molecular level.
  • Instrumentation and technique breakthroughs are crucial for advancing nanoscience.

Purpose of the Study:

  • To survey recent developments in observing, trapping, and probing single molecules in solution.
  • To highlight key instrumentation, particularly patents, in fluorescence imaging, optical tweezers, and anti-Brownian traps.
  • To identify trends in single-molecule analysis.

Main Methods:

  • Literature and patent review focusing on single-molecule observation, trapping, and probing techniques.
  • Analysis of instrumentation including fluorescence imaging, optical tweezers, and anti-Brownian traps.

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Single-Molecule F&ouml;rster Resonance Energy Transfer Methods for Real-Time Investigation of the Holliday Junction Resolution by GEN1
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Single-Molecule Förster Resonance Energy Transfer Methods for Real-Time Investigation of the Holliday Junction Resolution by GEN1

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Last Updated: Jun 27, 2026

Combining Single-molecule Manipulation and Imaging for the Study of Protein-DNA Interactions
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Combining Single-molecule Manipulation and Imaging for the Study of Protein-DNA Interactions

Published on: August 27, 2014

Automated System for Single Molecule Fluorescence Measurements of Surface-immobilized Biomolecules
10:57

Automated System for Single Molecule Fluorescence Measurements of Surface-immobilized Biomolecules

Published on: November 2, 2009

Single-Molecule F&ouml;rster Resonance Energy Transfer Methods for Real-Time Investigation of the Holliday Junction Resolution by GEN1
11:27

Single-Molecule Förster Resonance Energy Transfer Methods for Real-Time Investigation of the Holliday Junction Resolution by GEN1

Published on: September 18, 2019

  • Identification of trends from observation to active interrogation.

    • Main Results:

    • Recent patents cover enabling instrumentation for observing, trapping, and probing single molecules.
    • Specific instrumentation includes advancements in fluorescence imaging, optical tweezers, and anti-Brownian traps.
    • A trend towards active interrogation of single molecules is evident in recent research and patents.

    Conclusions:

    • Breakthroughs in instrumentation are vital for nanotechnology.
    • Patents reveal significant progress in tools for single-molecule analysis in solution.
    • The field is shifting from passive observation to active interrogation of single molecules.