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Updated: Jun 27, 2026

Proteomics to Identify Proteins Interacting with P2X2 Ligand-Gated Cation Channels
Published on: May 18, 2009
Membrane compartments and purinergic signalling: occurrence and function of P2X receptors in lung
Kathrin Barth1, Michael Kasper
1Institute of Anatomy, Medical Faculty 'Carl Gustav Carus', Dresden University of Technology, Germany. kathrin.barth@tu-dresden.de
Abstract:
P2X receptors are cation-selective ion channels activated by extracellular ATP. They form homo- and heterotrimeric complexes that differ in their functional properties and subcellular localization. These membrane ion channels are also expressed in pulmonary epithelial cells. Recent work indicates that alveolar epithelial type I cells selectively express P2X(4) and P2X(7) receptor subtypes in addition to a large number of other ion channels present in the alveolar epithelium. Up- or downregulation of their expression is associated with several disease states. This minireview analyses the role of P2X receptors and of extracellular ATP and adenosine in lung disease, the relationship of P2X receptors to other ion channels in the alveolar epithelium and their distribution in lipid rafts/caveolae.
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