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Basic and clinical immunology of Siglecs.

Stephan von Gunten1, Bruce S Bochner

  • 1Department of Medicine, Division of Allergy and Clinical Immunology, The Johns Hopkins University School of Medicine, Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224-6821, USA.

Annals of the New York Academy of Sciences
|December 17, 2008
PubMed
Summary

Sialic acid-binding immunoglobulin-like lectins (Siglecs) are immune cell surface proteins. This review details Siglec functions, ligands, and signaling, focusing on CD33-related Siglecs and their therapeutic potential.

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