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Related Experiment Video

Updated: Jun 27, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

Regulation and function of proinflammatory TH17 cells.

Gustavo J Martinez¹, Roza I Nurieva, Xuexian O Yang

¹Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA.

Annals of the New York Academy of Sciences

|December 17, 2008

Summary

Naïve CD4(+) T helper (TH) cells differentiate into effector cells, including the recently identified TH17 subset. TH17 cells play key roles in immune responses and various diseases, including autoimmune conditions and cancer.

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Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets

Mouse Naïve CD4⁺ T Cell Isolation and In vitro Differentiation into T Cell Subsets

Published on: April 16, 2015

Area of Science:

Immunology
Cell Biology
Molecular Biology

Background:

Naïve CD4(+) T helper (TH) cells differentiate into distinct effector subsets upon activation by antigen-presenting cells (APC).
TH1 and TH2 cells are well-characterized effector subsets, with TH17 cells recently identified as a third major subset.
TH17 cells are increasingly recognized for their significant roles in immunity and disease pathogenesis.

Purpose of the Study:

To review recent advancements in understanding TH17 cell differentiation and function.
To explore the cytokine-mediated regulation and transcriptional programming governing TH17 cell development.
To summarize the involvement of TH17 cells in various immune responses and disease contexts.

Main Methods:

This review synthesizes findings from recent scientific literature.
It focuses on studies investigating cytokine signaling pathways.
Transcriptional analysis of TH17 cell differentiation and function is discussed.

Main Results:

Cytokine profiles and immune regulatory functions distinguish TH17 cells from other effector TH subsets.
TH17 cells are implicated as critical players in infectious diseases, inflammatory conditions, autoimmune disorders, and cancer.
Specific regulatory mechanisms and transcriptional programs governing TH17 cell fate have been elucidated.

Conclusions:

TH17 cells represent a crucial effector T cell subset with diverse roles in immunity.
Understanding TH17 cell regulation is vital for developing therapeutic strategies for related diseases.
Further research into TH17 cell biology holds promise for advancing treatments in immunology and medicine.