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Updated: Jun 27, 2026

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Published on: September 27, 2024
Neuropeptides, mesenteric fat, and intestinal inflammation
Iordanes Karagiannides1, Charalabos Pothoulakis
1Inflammatory Bowel Disease Center, Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-7019, USA.
Obesity creates low-grade inflammation, and this review explores how fat tissue and neuropeptides may influence inflammatory bowel disease (IBD) like Crohn's disease.
Area of Science:
- Gastroenterology
- Immunology
- Metabolic Research
Background:
- Obesity is linked to low-grade inflammation and metabolic issues.
- Adipose tissue's role in inflammatory bowel disease (IBD) pathogenesis is largely unknown.
- Neuropeptides can promote inflammation and are implicated in IBD models.
Purpose of the Study:
- To review recent data on neuropeptide effects on adipose tissue.
- To explore the link between neuropeptide-activated adipose tissue and IBD, specifically Crohn's disease.
Main Methods:
- Literature review focusing on neuropeptide-adipose tissue interactions.
- Discussion integrating findings with IBD pathogenesis.
Main Results:
- Neuropeptides can influence non-inflammatory components of fat tissue.
- Adipose tissue may play a role in neuropeptide-driven intestinal inflammation.
Conclusions:
- Adipose tissue and neuropeptides are potential contributors to IBD pathogenesis.
- Further research is needed to elucidate these interactions in Crohn's disease.
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