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Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

Papillary Dermis

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...

Reticular Dermis

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...

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Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

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Dermatofibrosarcoma protuberans.

Vassilios A Dimitropoulos¹

¹Department of Dermatology, Rush University Medical Center, Chicago, Illinois 60612, USA. Vassilios_A_Dimitropoulos@rush.edu

Dermatologic Therapy

|December 17, 2008

Summary

This summary is machine-generated.

Dermatofibrosarcoma protuberans is a rare, locally invasive skin cancer. This condition often recurs after surgery, necessitating a thorough understanding of its characteristics and treatment.

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A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Area of Science:

Dermatology
Oncology
Pathology

Background:

Dermatofibrosarcoma protuberans (DFSP) is a rare malignant neoplasm of the skin.
DFSP is characterized by local invasiveness and a high recurrence rate post-excision.
It predominantly affects the trunk and proximal extremities.

Purpose of the Study:

To provide a comprehensive overview of dermatofibrosarcoma protuberans.
To discuss the epidemiology, clinical presentation, diagnostic methods, and histological findings.
To outline current treatment strategies for DFSP.

Main Methods:

Literature review and synthesis of existing data.
Discussion of epidemiological trends.
Analysis of clinical, diagnostic, and histological features.
Review of established and emerging treatment options.

Main Results:

DFSP presents unique epidemiological patterns.
Distinct clinical and histological features aid in diagnosis.
Wide local excision is a primary treatment, but recurrence is common.
Multidisciplinary approaches are often required for optimal management.

Conclusions:

Accurate diagnosis and understanding of DFSP behavior are crucial.
Effective management requires consideration of recurrence potential.
Further research into optimal treatment modalities is warranted.