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Updated: Jun 27, 2026
09:37
Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
Published on: August 18, 2022
Eccrine porocarcinoma
Clarence William Brown1, Lady Christine Dy
1Department of Dermatology, Rush University Medical Center, Chicago, Illinois 60612, USA. Clarence_W_Brown@rush.edu
Dermatologic Therapy
|December 17, 2008
Summary
Eccrine porocarcinoma (EPC) is a rare skin cancer. Mohs micrographic surgery (MMS) offers the best chance for clear margins and cure, especially when diagnosed early and without metastasis.
Area of Science:
- Dermatology
- Oncology
- Surgical Pathology
Background:
- Eccrine porocarcinoma (EPC) is a rare, slow-growing malignant skin neoplasm.
- It can arise de novo or from a benign eccrine poroma.
- Histologically, it features anaplastic cells in the epidermis and dermis, with potential for metastasis.
Purpose of the Study:
- To review the current literature on eccrine porocarcinoma.
- To evaluate the efficacy of various treatment modalities for EPC.
- To identify the optimal therapeutic approach for achieving clear margins and cure.
Main Methods:
- Literature review of eccrine porocarcinoma cases and treatments.
- Analysis of treatment outcomes including standard excision, Mohs micrographic surgery (MMS), chemotherapy, and radiation therapy.
- Evaluation of sentinel lymph node biopsy as a staging tool.
Main Results:
- Mohs micrographic surgery (MMS) provides the highest likelihood of achieving clear margins.
- MMS is associated with the greatest chance of cure in cases without regional or distant metastases.
- Sentinel lymph node biopsy is emerging as a valuable staging tool.
Conclusions:
- Eccrine porocarcinoma requires careful management due to its malignant potential and metastatic capability.
- Mohs micrographic surgery (MMS) is the preferred treatment for localized EPC, maximizing cure rates.
- Further investigation into sentinel lymph node biopsy is warranted for accurate staging and treatment planning.
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