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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Leishmaniasis01:30

Leishmaniasis

Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...

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Related Experiment Video

Updated: Jun 27, 2026

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

Lentigo maligna.

Gert J Smalberger1, Daniel Mark Siegel, Amor Khachemoune

  • 1Department of Pathology, SUNY Downstate, Brooklyn, New York, USA.

Dermatologic Therapy
|December 17, 2008
PubMed
Summary
This summary is machine-generated.

Lentigo maligna (LM), a type of melanoma in situ, commonly affects sun-exposed skin in individuals over 40. This review covers its history, diagnosis, and treatment challenges.

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Lentigo maligna (LM) is a melanoma in situ affecting sun-exposed skin.
  • It predominantly occurs in Caucasian individuals over 40 years old.
  • Incidence increases with age, peaking in older adults.

Purpose of the Study:

  • To provide a comprehensive review of lentigo maligna (LM).
  • To discuss the challenges in diagnosing and treating LM.
  • To cover the history, epidemiology, clinical presentation, histology, and treatment of LM.

Main Methods:

  • Literature review of lentigo maligna (LM).
  • Synthesis of information on LM history, epidemiology, clinical features, histology, and treatment modalities.
  • Analysis of diagnostic and therapeutic challenges.

Main Results:

  • Lentigo maligna (LM) is a common melanoma in situ.
  • Diagnosis and treatment of LM present significant clinical challenges.
  • The review consolidates current knowledge on LM across various aspects.

Conclusions:

  • Lentigo maligna (LM) requires careful management due to diagnostic and treatment complexities.
  • Understanding LM's epidemiology and clinical presentation is crucial for early detection.
  • Further research may improve LM treatment outcomes.