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Updated: Jun 27, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Treatment-resistant diffuse calcinosis in scleroderma.

S Vasudevan1, B Zimmermann, E V Lally

  • 1Department of Medicine, Division of Rheumatology, Roger Williams Medical Center and Brown University School of Medicine, Providence, Rhode Island.

Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases
|December 17, 2008
PubMed
Summary
This summary is machine-generated.

This case study details severe subcutaneous calcification in limited cutaneous systemic sclerosis, highlighting treatment resistance. Analysis identified hydroxyapatite and octacalcium phosphate crystals in the calcinosis.

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Last Updated: Jun 27, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Area of Science:

  • Rheumatology
  • Dermatology
  • Crystal Arthropathies

Background:

  • Systemic sclerosis is an autoimmune disease characterized by fibrosis and vascular abnormalities.
  • Limited cutaneous systemic sclerosis (lcSSc) can present with subcutaneous calcification (calcinosis).
  • Calcinosis in lcSSc can lead to significant morbidity and treatment challenges.

Purpose of the Study:

  • To present a case of lcSSc with severe, diffuse subcutaneous calcification.
  • To analyze the composition of calcific crystals in this patient.
  • To review potential treatment strategies for calcinosis in scleroderma.

Main Methods:

  • Case report of a patient with lcSSc and extensive calcinosis.
  • Clinical assessment of complications and treatment response.
  • Analysis of calcific crystal composition using [specific analytical technique - if known, otherwise omit or generalize].

Main Results:

  • The patient presented with severe, diffuse subcutaneous calcification.
  • Calcinosis led to multiple complications.
  • The patient was refractory to all attempted treatments.
  • Crystal analysis revealed hydroxyapatite and octacalcium phosphate.

Conclusions:

  • Severe subcutaneous calcification is a debilitating complication of lcSSc.
  • Calcinosis in this case was resistant to therapy.
  • Hydroxyapatite and octacalcium phosphate are key crystalline components.
  • Further research into effective calcinosis treatments for scleroderma is warranted.