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Updated: Jun 27, 2026
04:08
Metacarpal Small Incision for Carpal Tunnel Syndrome
Published on: April 5, 2024
Gouty tophus causing tarsal tunnel syndrome
A Estrada1, R Hall, S Martinez
1Division of Rheumatology, Allergy and Immunology, Department of Medicine, (A.E., N.B.A.), Department of Orthopaedic Surgery (R.H.), and the Department of Radiology (S.M.), Duke University Medical Center, Durham, North Carolina.
Summary
Tarsal tunnel syndrome (TTS) can stem from various causes. This study details the first reported case of TTS caused by a tophaceous mass, expanding the known etiologies of this condition.
Area of Science:
- Orthopedics
- Neurology
- Rheumatology
Background:
- Tarsal tunnel syndrome (TTS) is a nerve entrapment condition.
- Known causes include trauma, tumors, and inflammatory conditions like rheumatoid arthritis and hypothyroidism.
Purpose of the Study:
- To report the first case of TTS caused by a tophaceous mass.
- To review the known etiologies, clinical presentation, and diagnostic methods for TTS.
- To survey pseudotumor crystal-induced lesions and tophi in unusual locations.
Main Methods:
- Case report of a patient with TTS.
- Literature review of TTS etiologies and diagnostics.
- Review of literature on crystal-induced lesions and tophi.
Main Results:
- The first documented case of tarsal tunnel syndrome attributed to a tophaceous mass is presented.
- A comprehensive review of established and rare causes of TTS is provided.
- Information on pseudotumor crystal-induced lesions and atypical tophi is summarized.
Conclusions:
- Topha should be considered in the differential diagnosis of tarsal tunnel syndrome.
- This case broadens the understanding of potential causes for nerve entrapment in the tarsal tunnel.
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