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Related Concept Videos

Skeletal Muscle Relaxants: Adverse Effects01:21

Skeletal Muscle Relaxants: Adverse Effects

Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...
Skeletal Muscle Relaxants: Therapeutic Uses01:31

Skeletal Muscle Relaxants: Therapeutic Uses

Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx as...
Classification of Skeletal Muscle Relaxants01:28

Classification of Skeletal Muscle Relaxants

Skeletal muscle relaxants are a group of drugs that can reduce muscle stiffness and induce temporary paralysis to relieve pain. These agents can act centrally to reduce muscle tone or spasms in painful conditions such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), or spinal injuries; they are called antispasmodics or spasmolytics.
Peripherally acting skeletal muscle relaxants interfere with the neurotransmission at the neuromuscular end plate to induce paralysis during...
Peripherally and Centrally Acting Muscle Relaxants: A Comparison01:09

Peripherally and Centrally Acting Muscle Relaxants: A Comparison

Skeletal muscle relaxants can target the central nervous system [CNS] to reduce muscle tension or act directly at the neuromuscular junction to induce temporary paralysis. These two classes of muscle relaxants are called centrally acting muscle relaxants and peripherally acting muscle relaxants. They differ in their action, mechanism, administration route, and clinical uses.
Centrally acting muscle relaxants can be further divided into spasmolytic and antispasmodic drugs. Spasmolytic drugs,...
Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...

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A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers
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Fibromyalgia consensus report: additional comments.

M B Yunus1, R M Bennett, T J Romano

  • 1University of Illinois College of Medicine at Peoria, Peoria, Illinois Oregon Health Sciences University, Portland, Oregon Professional Center III, Wheeling, West Virginia University of Texas Health Science Center, San Antonio, Texas.

Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases
|December 17, 2008
PubMed
Summary
This summary is machine-generated.

This paper reviews the 1996 fibromyalgia syndrome (FMS) consensus report, emphasizing the need to integrate clinical experience with research data for better patient care and acknowledging the report's time limitations.

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Area of Science:

  • Rheumatology
  • Clinical Medicine
  • Patient Care

Background:

  • The 1996 fibromyalgia syndrome (FMS) consensus report generated controversy.
  • The report provided valuable information but some aspects may be misinterpreted.
  • Misinterpretations can negatively impact patient care, particularly regarding diagnosis and management.

Purpose of the Study:

  • To examine the 1996 FMS consensus report.
  • To offer additional perspectives on FMS diagnosis, causality, and management.
  • To advocate for the integration of clinical experience with research data.

Main Methods:

  • Critical review of the 1996 FMS consensus report.
  • Analysis of specific controversial viewpoints within the report.
  • Synthesis of research data and clinical experience.

Main Results:

  • The consensus report's findings on FMS are valuable but require careful interpretation.
  • Certain aspects, like diagnosis in work settings and causality, risk misapplication.
  • Integrating clinical insights with scientific data is crucial for effective FMS management.

Conclusions:

  • Both research data and clinical experience are essential for addressing FMS.
  • The 1996 report's conclusions, compiled in 1994, should be viewed within their time limitations.
  • A balanced approach is necessary to prevent detrimental misinterpretations in patient care.