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Related Concept Videos

Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
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Minocycline hyperpigmentation.

E J Messner1, D R Finger, M A Crowe

  • 1Department of Medicine (EJM), Rheumatology Service (DRF), Dermatology Service (MAC), Department of Pathology (MCR), Madigan Army Medical Center, Tacoma, WA 98433.

Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases
|December 17, 2008
PubMed
Summary
This summary is machine-generated.

Minocycline is effective for rheumatoid arthritis but can cause skin hyperpigmentation. Factors like steroid use and age may increase risk, requiring physician awareness and potential discontinuation of the drug.

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Area of Science:

  • Dermatology
  • Rheumatology
  • Pharmacology

Background:

  • Minocycline is utilized for mild rheumatoid arthritis, with common side effects including GI issues and headaches.
  • Skin hyperpigmentation is a less common, typically dose-related side effect of minocycline.
  • This review details hyperpigmentation types, pathology, clinical presentation, risk factors, and treatments.

Purpose of the Study:

  • To review the literature on minocycline-induced hyperpigmentation.
  • To identify potential risk factors for developing hyperpigmentation.
  • To inform physicians about this adverse effect and its management.

Main Methods:

  • Literature review on minocycline and hyperpigmentation.
  • Analysis of clinical experience and patient data.
  • Discussion of histopathological and clinical distinctions of hyperpigmentation.

Main Results:

  • Common minocycline side effects are mild; hyperpigmentation is less frequent but noted.
  • Potential risk factors include steroid use, advanced age, cumulative dosage, and minocycline brand.
  • Most patients continued minocycline despite hyperpigmentation (61%), but discontinuation is necessary for resolution.

Conclusions:

  • Minocycline-induced hyperpigmentation may be more prevalent than recognized.
  • Physicians should monitor patients for skin hyperpigmentation during minocycline treatment.
  • Discontinuation of minocycline is required for hyperpigmentation to resolve.