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Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
Published on: May 10, 2024
Diffuse fasciitis with eosinophilia (shulman syndrome)
Wiliam E Owens1, Tulio E Bertorini, Hugh T Holt
1From the *Department of Neurology, University of Tennessee, Memphis, TN; daggerCenter for the Diagnosis and Treatment of Neurological Disorders, Wesley Neurology Clinic, Memphis, TN; double daggerMethodist Hospital, Memphis, TN; and section signDepartment of Pathology, Wesley Neuromuscular Lab, Memphis, TN.
Journal of Clinical Neuromuscular Disease
|December 17, 2008
Summary
A patient with hypereosinophilia experienced generalized edema and joint pain. This case highlights eosinophilic fasciitis (Shulman syndrome), emphasizing the need for combined fascia and muscle biopsies for diagnosis.
Area of Science:
- Rheumatology
- Dermatology
- Pathology
Background:
- Hypereosinophilia can manifest with diverse systemic symptoms.
- Fasciitis and perimyositis occurring together suggest a specific connective tissue disease spectrum.
- Eosinophilic fasciitis, also known as Shulman syndrome, is a rare inflammatory condition.
Purpose of the Study:
- To report a case of a 46-year-old female presenting with generalized edema and arthralgias.
- To illustrate the clinical presentation of hypereosinophilia associated with diffuse fasciitis and perimyositis.
- To emphasize diagnostic considerations for eosinophilic fasciitis.
Main Methods:
- Clinical presentation review of a patient with generalized edema and arthralgias.
- Laboratory evaluation including assessment for hypereosinophilia.
- Histopathological examination of tissue biopsies.
Main Results:
- The patient presented with generalized edema and arthralgias.
- Hypereosinophilia was identified.
- The patient exhibited diffuse fasciitis and perimyositis.
Conclusions:
- The co-occurrence of fasciitis and perimyositis in a patient with hypereosinophilia is consistent with eosinophilic fasciitis (Shulman syndrome).
- Combined fascia and muscle biopsy is recommended for accurate diagnosis in patients presenting with muscle pain and inflammation.
- Early recognition and appropriate biopsy can guide management of eosinophilic fasciitis.
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