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Updated: Jun 27, 2026
08:59
A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
Published on: January 5, 2017
[Malignant multiple neoplasms in head and neck squamous cell carcinoma]
Celia López Mollá1, Enrique Estellés Ferriol, Marina Carrasco Llatas
1Servicio de Otorrinolaringología, Hospital Universitario Dr. Peset, Valencia, España. celia.lopez.molla@gmail.com
Acta Otorrinolaringologica Espanola
|December 17, 2008
Summary
Multiple malignant neoplasms are common in head and neck cancers, occurring in 7.73% of cases. Early detection through regular check-ups is crucial as these secondary cancers significantly worsen patient prognosis.
Area of Science:
- Oncology
- Head and Neck Surgery
- Cancer Epidemiology
Context:
- The upper aerodigestive tract has a high incidence of multiple malignant neoplasms, ranging from 7% to 20%.
- Head and neck squamous cell carcinomas represent a significant proportion of these cases.
- Understanding the characteristics and survival outcomes of these multiple neoplasms is critical for patient management.
Purpose:
- To evaluate the incidence, main characteristics, and survival rates of multiple malignant neoplasms in patients with head and neck squamous cell carcinomas.
- To identify primary tumor sites and associated secondary cancers.
- To analyze the impact of multiple malignant neoplasms on patient prognosis.
Summary:
- A retrospective study analyzed 103 cases of multiple malignant neoplasms from 1330 patients with head and neck squamous cell carcinomas.
- The incidence of multiple malignant neoplasms in this series was 7.73%.
- Hypopharyngeal tumors (21.34%) and oropharyngeal tumors (15.38%) were most frequently associated with multiple primary tumors, while lung tumors (29.03%) were the most common secondary malignancy. The 5-year survival rate was 33%, with metachronous tumors accounting for 78.02% and an average delay of 40 months between diagnoses.
Impact:
- Highlights the significant frequency of multiple malignant neoplasms in the head and neck region.
- Emphasizes the critical need for thorough and regular patient check-ups.
- Underscores that the presence of multiple malignant neoplasms considerably worsens the prognosis, necessitating proactive surveillance and management strategies.
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