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Updated: Jul 5, 2025

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Risk of cancer in patients with sleep apnea: comparison of surgery versus CPAP in a long-term follow-up study
Carlos O'Connor-Reina1,2, Laura Rodriguez Alcala3,4, Jose Maria Ignacio5
1Otorhinolaryngology Department, Hospital Quironsalud Marbella, 29680, Marbella, Spain. carlos.oconnor@quironsalud.es.
Purpose:
This study aimed to obtain a comprehensive view of the risk of developing cancer in patients with obstructive sleep apnea (OSA) and to compare this risk between patients receiving continuous positive airway pressure (CPAP) therapy versus upper airway surgery (UAS).
Methods:
We used both local data and a global-scale federated data research network, TriNetX, to access electronic medical records, including those of patients diagnosed with OSA from health-care organizations (HCOs) worldwide. We used propensity score matching and the score-matched analyses of data for 5 years of follow-up, RESULTS: We found that patients who had undergone UAS had a similar risk of developing cancer than those who used CPAP [hazard ratio of 0.767 (95% CI 0.559-1.053; P = 0.100)].
Conclusion:
Analysis of the large data sets collected from HCOs in Europe and globally lead us to conclude that in patients with OSA, neither CPAP nor UAS were associated with the development of cancer better than in non-treated patients.
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