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Related Concept Videos

Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...

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Updated: Jun 27, 2026

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
07:26

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis

Published on: January 31, 2025

Hedgehog signaling in development and cancer.

Jin Jiang1, Chi-Chung Hui

  • 1Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA. jin.jiang@utsouthwestern.edu

Developmental Cell
|December 17, 2008
PubMed
Summary

The Hedgehog (Hh) signaling pathway is crucial for embryonic development and tissue repair. This review covers Hh gradient formation, signal transduction, and its roles in development and cancer.

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Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Cell Biology

Background:

  • The Hedgehog (Hh) family of secreted proteins plays vital roles in embryonic development and maintaining adult tissue homeostasis.
  • Understanding Hh signaling is key to comprehending complex biological processes.

Purpose of the Study:

  • To review the current knowledge on Hedgehog (Hh) morphogen gradient formation and signal transduction.
  • To explore the diverse roles of Hh signaling in embryonic development and tumorigenesis.
  • To discuss the evolutionary divergence and pathway integration of Hh signaling.

Main Methods:

  • Literature review of existing research on Hedgehog signaling.
  • Analysis of molecular and cellular mechanisms underlying Hh pathway function.
  • Synthesis of information on Hh's role in development and disease.

Main Results:

  • Hh signaling involves intricate gradient formation and signal transduction mechanisms.
  • Hh pathways are essential for various developmental processes and tissue homeostasis.
  • Dysregulation of Hh signaling is implicated in tumorigenesis.
  • Hh signaling integrates with other pathways to regulate cell growth and patterning.

Conclusions:

  • Hedgehog signaling is a fundamental pathway with conserved and diverged roles across species.
  • Further research into Hh pathway dynamics and interactions can offer insights into developmental disorders and cancer therapies.