Related Experiment Video
Updated: Jun 27, 2026

LPS and ATP-induced Death of PMA-differentiated THP-1 Macrophages and its Validation
Published on: May 3, 2024
Role of Programmed Cell Death in the Immunopathogenesis of Sepsis
Mario Perl1, Chun-Shiang Chung, Ryan Swan
1Division of Surgical Research, Department of Surgery, Rhode Island Hospital/ Brown University, School of Medicine, Providence, RI 02903.
Abstract:
Apoptosis is an important mechanism during the immunopathogenesis of sepsis. Early programmed cell death of lymphocytes substantially impairs innate and adaptive immunity reducing the capacity to ward off the invading pathogen. Apoptosis of parenchymal cells (e.g. in the lung, liver and gut) may also promote organ failure and death. Several experimental therapeutic strategies have now been developed to beneficially influence these mechanisms; however, their potential clinical benefit is yet to be evaluated.
Related Concept Videos
Overview of Cell Death
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the 20th century...
Cellular Injury IlI: Cellular Death
Cellular Injury V: Apoptosis and Autophagy
The Extrinsic Apoptotic Pathway
Caspases
Necrosis
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...

