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Updated: Dec 24, 2025

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS
Published on: April 7, 2021
The renin-angiotensin system in acute respiratory distress syndrome
Yumiko Imai1, Keiji Kuba1, Josef M Penninger1
1Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Dr Bohr-gasse 3, A-1030 Vienna, Austria.
Abstract:
Angiotensin-converting enzyme 2 (ACE2) counterbalances with ACE and functions as a negative regulator of the renin-angiotensin system (RAS). The importance of RAS in acute respiratory distress syndrome (ARDS) has recently re-emerged owing to the identification of ACE2 as a receptor for the SARS-coronavirus. Recent studies have demonstrated that ACE2 protects mice from acute lung injury as well as SARS-mediated lung injury. We review the role of the RAS, in particular ACE2, in the pathogenesis of ARDS.
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