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Oral ofloxacin therapy for invasive external otitis.

D Zikk¹, Y Rapoport, C Redianu

¹Department of Otorhinolaryngology, Tel Aviv Sourasky Medical Center, Ichilov Hospital, Israel.

The Annals of Otology, Rhinology, and Laryngology

|August 1, 1991

Summary

Oral ofloxacin effectively treated pseudomonal invasive external otitis (IEO) in adults, with an 83.3% cure rate. This convenient therapy showed minimal side effects, though some cases developed resistance or allergic reactions.

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Area of Science:

Infectious Diseases
Otolaryngology
Pharmacology

Background:

Pseudomonal invasive external otitis (IEO) is a serious infection often affecting elderly patients with underlying conditions like diabetes mellitus.
Pseudomonas aeruginosa is a common pathogen in IEO, necessitating effective antimicrobial treatment.

Purpose of the Study:

To evaluate the clinical efficacy and safety of oral ofloxacin in treating pseudomonal IEO.
To assess the outcomes in patients with mild versus severe forms of the disease.

Main Methods:

A study involving 24 adult patients with pseudomonal IEO, divided into mild (Group A) and severe (Group B) forms.
Patients received oral ofloxacin at 400 mg twice daily.
Clinical outcomes, pathogen identification, and adverse events were monitored.

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Main Results:

An overall cure rate of 83.3% was achieved with oral ofloxacin treatment.
Two patients required multiple treatment courses for cure.
Three cases of P. aeruginosa resistance to ofloxacin and one severe allergic reaction led to treatment discontinuation.
Minor side effects including nausea, arthralgia, and vaginal itching were reported.

Conclusions:

Oral ofloxacin is an effective, convenient, safe, and economical treatment option for IEO caused by susceptible organisms.
The study highlights the potential for ofloxacin resistance and allergic reactions, necessitating careful patient monitoring.