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Updated: Jun 27, 2026
Attaching Biological Probes to Silica Optical Biosensors Using Silane Coupling Agents
Published on: May 1, 2012
Multi-modal 19F NMR probe using perfluorinated cubic silsesquioxane-coated silica nanoparticles for monitoring
Kazuo Tanaka1, Narufumi Kitamura, Kensuke Naka
1Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto, 615-8510, Japan.
Abstract:
The establishment of (19)F NMR signal regulation and the application of this strategy to develop a multi-modal (19)F NMR probe for monitoring enzymatic activity using nanoparticles as a signal regulator is described; water-soluble perfluorinated cubic silsesquioxane was synthesized and immobilized onto the silica nanoparticles for suppressing the signals; (19)F NMR signals of the probes were recovered by releasing from nanoparticles.
