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Electrocardiographic and echocardiographic changes in perinatal asphyxia
P S Rajakumar1, B Vishnu Bhat, M G Sridhar
1Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Indian Journal of Pediatrics
|December 17, 2008
Summary
Cardiac troponin-T assays effectively evaluate myocardial damage in newborns experiencing perinatal asphyxia. This cardiac enzyme measurement correlates with disease severity and patient outcomes, offering a valuable diagnostic tool.
Area of Science:
- Neonatal Medicine
- Cardiology
- Biochemistry
Background:
- Perinatal asphyxia poses a significant risk of myocardial damage in term infants.
- Accurate assessment of cardiac involvement is crucial for predicting outcomes.
Purpose of the Study:
- To determine the utility of cardiac enzymes, specifically troponin-T and CK-MB, in assessing myocardial injury in perinatal asphyxia.
- To compare the diagnostic performance of troponin-T and CK-MB.
Main Methods:
- A case-control study involving 30 term infants with perinatal asphyxia and 30 healthy controls.
- Evaluation of myocardial dysfunction through clinical assessment, ECG, echocardiography, and measurement of cardiac enzymes (troponin-T, CK-MB).
Main Results:
- Elevated cardiac enzyme levels were observed in infants with perinatal asphyxia compared to controls.
- Troponin-T demonstrated higher sensitivity and specificity than CK-MB in detecting myocardial involvement.
- Troponin-T levels correlated significantly with the severity and clinical outcome of perinatal asphyxia.
Conclusions:
- Cardiac troponin-T assay is a valuable tool for assessing the severity of myocardial damage in perinatal asphyxia.
- Troponin-T levels can aid in predicting the outcome for affected neonates.
