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On chip cell separator using magnetic bead-based enrichment and depletion of various surface markers

Matthew D Estes1, Jaephil Do, Chong H Ahn

  • 1Department of Biomedical Engineering, MicroSystems and BioMEMS Lab, University of Cincinnati, 814 Rhodes Hall, Cincinnati, OH 45221, USA. estesmd@email.uc.edu

Biomedical Microdevices
|December 17, 2008
PubMed

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Cell separation was first achieved in 1964 by S. H. Seal, who separated large tumor cells from the smaller blood cells using filtration. Two years later, Pohl and Hawk performed experiments on how cells respond differently to a nonuniform electric field based on the cell type. Such observations were the inception of cell separation methods, which allow isolating a single cell type from a heterogeneous sample.