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Related Experiment Video

Updated: Jun 27, 2026

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model
13:04

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model

Published on: March 18, 2015

Stem cells and scaffolds for vascularizing engineered tissue constructs.

E Luong1, S Gerecht

  • 1Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD, 21218, USA.

Advances in Biochemical Engineering/Biotechnology
|December 17, 2008
PubMed
Summary
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Tissue engineering aims to create functional vascular networks using biodegradable scaffolds and cell sources like human embryonic stem cells (hESCs) and endothelial progenitor cells (EPCs). This research explores advances in generating vascular tissue for therapeutic applications.

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Cell Biology

Background:

  • Tissue engineering seeks to replicate natural tissue development for regeneration.
  • Functional vascular network creation is crucial for tissue engineering applications.
  • Biodegradable materials serve as templates for tissue growth.

Purpose of the Study:

  • To review advances in generating functional vascular tissue.
  • To focus on scaffolds and cell sources for vascular tissue engineering.
  • To explore the potential of human embryonic stem cells (hESCs) and endothelial progenitor cells (EPCs).

Main Methods:

  • Utilizing biodegradable and bioactive materials as scaffolds.
  • Employing human embryonic stem cells (hESCs) for differentiation into vascular cells.

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Stepwise Cell Seeding on Tessellated Scaffolds to Study Sprouting Blood Vessels

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A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo
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A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo

Published on: August 28, 2014

Related Experiment Videos

Last Updated: Jun 27, 2026

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model
13:04

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model

Published on: March 18, 2015

Stepwise Cell Seeding on Tessellated Scaffolds to Study Sprouting Blood Vessels
07:49

Stepwise Cell Seeding on Tessellated Scaffolds to Study Sprouting Blood Vessels

Published on: January 14, 2021

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo
07:56

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo

Published on: August 28, 2014

  • Investigating human ESC-derived endothelial progenitor cells (hEPCs) and adult EPCs for microvessel formation.

    • Main Results:

    • hESCs can differentiate and form blood vessels via vasculogenesis.
    • hESC-derived EPCs and endothelial cells show potential for microvessel formation in vitro and in vivo.
    • Adult EPCs are being studied for their regulatory biology and therapeutic potential in vascular repair.

    Conclusions:

    • Advances in scaffolds and cell sources are key to functional vascular tissue engineering.
    • hESCs and EPCs offer promising avenues for therapeutic vascularization.
    • Further research into EPC regulation and differentiation is vital for cellular therapies.