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Updated: Jun 27, 2026

Imaging Pheromone Sensing in a Mouse Vomeronasal Acute Tissue Slice Preparation
09:31

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Published on: December 6, 2011

Pheromone sensing in mice.

I Rodriguez1, U Boehm

  • 1Department of Zoology and Animal Biology, University of Geneva, 30 Quai Ernest Ansermet, Geneva, 1211, Switzerland. Ivan.Rodriguez@zoo.unige.ch

Results and Problems in Cell Differentiation
|December 17, 2008
PubMed
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Rodents use both main and accessory olfactory systems to detect pheromones. Gene-targeted mice reveal these systems converge to influence complex behaviors and hormonal changes.

Area of Science:

  • Neuroscience
  • Olfactory system research
  • Animal behavior

Background:

  • The vomeronasal organ (VNO) is part of the accessory olfactory system in rodents, crucial for pheromone detection.
  • Identifying specific vomeronasal agonists is challenging due to the diversity of chemical structures and co-activation of main olfactory neurons.
  • Pheromones trigger complex behavioral and hormonal responses in mice.

Purpose of the Study:

  • To investigate the distinct and overlapping roles of the main and accessory olfactory systems in pheromone sensing.
  • To elucidate the functional contribution of different chemosensory epithelia to pheromone detection in mice.

Main Methods:

  • Utilizing gene-targeted mice with selective disruptions in vomeronasal or main olfactory signaling pathways.

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Last Updated: Jun 27, 2026

Imaging Pheromone Sensing in a Mouse Vomeronasal Acute Tissue Slice Preparation
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Imaging Pheromone Sensing in a Mouse Vomeronasal Acute Tissue Slice Preparation

Published on: December 6, 2011

In-depth Physiological Analysis of Defined Cell Populations in Acute Tissue Slices of the Mouse Vomeronasal Organ
10:11

In-depth Physiological Analysis of Defined Cell Populations in Acute Tissue Slices of the Mouse Vomeronasal Organ

Published on: September 10, 2016

Assessment of Sexual Behavior of Male Mice
04:38

Assessment of Sexual Behavior of Male Mice

Published on: March 5, 2020

  • Analyzing the behavioral and hormonal outcomes in response to pheromonal stimuli.

    • Main Results:

    • Pheromones are detected by a diverse range of chemical compounds, including peptides and protein fragments.
    • Both main and accessory olfactory systems are activated by many pheromones, complicating functional analysis.
    • Gene-targeted mouse models demonstrated that both olfactory systems play a role in pheromone processing.

    Conclusions:

    • The main and accessory olfactory systems in rodents are not mutually exclusive but can converge and synergize.
    • Combined signaling through both systems is essential for the full expression of pheromone-induced behaviors and physiological changes.