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Dye diffusion from microcapsules with different shell thickness into mammalian skin.

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Area of Science:

  • Materials Science
  • Dermatology
  • Chemical Engineering

Background:

  • Microencapsulation is crucial for controlled delivery of active compounds.
  • Understanding topical delivery into skin layers is vital for cosmetic and pharmaceutical applications.
  • The stratum corneum presents a significant barrier to topical penetration.

Purpose of the Study:

  • To fabricate oil-in-water microcapsules with tunable shell thicknesses using coacervation.
  • To evaluate the topical delivery and penetration of a lipophilic dye encapsulated within these microcapsules on porcine skin.
  • To model the diffusion kinetics of the dye through the microcapsule shell and skin.

Main Methods:

  • Fabrication of oil-in-water microcapsules via solvent evaporation-induced coacervation.
  • Encapsulation of a lipophilic dye within the microcapsule cores.
  • Topical application of microcapsules onto porcine skin for 6 hours, followed by analysis.
  • Mathematical modeling to estimate diffusion coefficients.

Main Results:

  • Microcapsules successfully encapsulated a lipophilic dye.
  • Topical application resulted in preferential dye accumulation in skin furrows and hair follicles.
  • No significant dye penetration beyond the stratum corneum was observed.
  • Estimated diffusion coefficients: 10⁻¹⁸ m²/s (microcapsule shell) and 10⁻¹⁶ m²/s (skin).

Conclusions:

  • Coacervation is an effective technique for creating microcapsules for topical delivery.
  • The microcapsule shell and the stratum corneum limit dye diffusion, confining it to superficial skin structures.
  • The study provides quantitative insights into microcapsule-skin interaction and diffusion parameters.