Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Cirrhosis II: Pathophysiology01:24

Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mutant KRAS peptide vaccine with dual checkpoint blockade in metastatic colorectal cancer: a phase I trial.

Nature communications·2026
Same author

QuaDB: A streamlined web tool for identifier-based rapid prediction of putative quadruplex sequences.

Human genomics·2026
Same author

Simultaneous CRISPR/Cas9-induced double-strand breaks are lethal in models of pancreatic cancer.

The Journal of clinical investigation·2026
Same author

Publisher Correction: Mutant KRAS vaccine with dual checkpoint blockade in resected pancreatic cancer: a phase I trial.

Nature communications·2026
Same author

The combination of a cancer vaccine, pembrolizumab, and stereotactic body radiation in patients with locally advanced pancreatic cancer: a single-arm, phase II study.

Nature communications·2026
Same author

AXIN1 Mutated Hepatocellular Carcinoma.

The American journal of surgical pathology·2026
Same journal

Clinical Impact of Second Opinion Consultation in Bladder Biopsies and Transurethral Resection of Bladder Tumors.

Human pathology·2026
Same journal

Prognostic relevance and molecular correlates of Claudin-1 expression in pancreatic neuroendocrine tumors.

Human pathology·2026
Same journal

Mixed Phenotype Acute Leukemia: Lineage Assignment, Immunophenotypic Classification and Genetic Insights.

Human pathology·2026
Same journal

Chronic myelomonocytic leukemia revisited: A comprehensive review with emphasis on the oligomonocytic subtype.

Human pathology·2026
Same journal

Artificial intelligence-assisted screening for NTRK fusion-positive salivary gland tumors: A novel digital pathology workflow.

Human pathology·2026
Same journal

Evaluation of prognostic factors and outcomes in primary versus secondary myeloid sarcoma.

Human pathology·2026
See all related articles

Related Experiment Video

Updated: Jun 27, 2026

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
11:36

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Published on: May 29, 2020

Hepatitis in common variable immunodeficiency.

Jason A Daniels1, Michael Torbenson, Perumal Vivekanandan

  • 1Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. jason.daniels@allina.com

Human Pathology
|December 17, 2008
PubMed
Summary
This summary is machine-generated.

Common variable immunodeficiency (CVID) liver biopsies show mild inflammation without significant fibrosis. Findings suggest potential links to gastrointestinal inflammation, though the exact cause of CVID hepatitis remains unclear.

More Related Videos

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
09:03

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice

Published on: February 3, 2012

Related Experiment Videos

Last Updated: Jun 27, 2026

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
11:36

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Published on: May 29, 2020

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
09:03

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice

Published on: February 3, 2012

Area of Science:

  • Immunology
  • Hepatology
  • Gastroenterology

Background:

  • Common variable immunodeficiency (CVID) is a primary immunodeficiency disease.
  • A hallmark of CVID is reduced plasma cells in gut biopsies.
  • Chronic inflammation in CVID can impact organs like the liver.

Purpose of the Study:

  • To characterize the histological liver biopsy findings in patients with CVID.
  • To investigate potential associations between liver inflammation and gastrointestinal issues in CVID.

Main Methods:

  • Retrospective analysis of 13 liver biopsies from 10 CVID patients.
  • Review of histological features including inflammation, fibrosis, and granulomas.
  • Correlation with concurrent intestinal biopsy findings where available.

Main Results:

  • Mild portal and lobular chronic inflammation were common findings.
  • Plasma cells were absent in all liver biopsies.
  • No or mild portal fibrosis was observed, with no progression in follow-up biopsies.
  • Granulomas were present in a subset of patients, some with coexistent sarcoidosis.
  • Intestinal inflammation was noted in 5 out of 7 patients with concurrent biopsies.

Conclusions:

  • Liver biopsies in CVID patients typically exhibit mild inflammation and minimal fibrosis.
  • The observed liver changes may be linked to gastrointestinal inflammation and antigen translocation.
  • The precise etiology of hepatitis in CVID requires further investigation.