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Light- and electron-microscopical study of a case of gold salt-induced hepatotoxicity

G M Fleischner1, R Morecki, T Hanaichi

  • 1Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461.

Hepatology (Baltimore, Md.)
|September 1, 1991
PubMed

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Immunoelectron microscopy utilizes immunogold labeling of endogenous proteins with specific antibodies to detect and localize these proteins in cells and tissues. The procedure provides insights into the distribution and quantification of protein under different stimulation conditions offering clues about their functions. Conjugating highly electron-dense gold particles with primary or secondary antibodies allow antigen detection on and within cells, with high resolution and specificity.