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Updated: Jun 27, 2026
06:38
Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines
Published on: November 8, 2011
[Febrile cellulitis surrounding a scar revealing a large immunoblastic B-cell lymphoma]
M Charavin-Cocuzza1, I Templier, A Simon
1Pôle pluridisciplinaire de médecine, service de dermatologie, CHU Albert-Michallon, BP 217, 38043 Grenoble cedex 09, France.
Annales De Dermatologie Et De Venereologie
|December 17, 2008
Summary
This case study details a rare instance where diffuse immunoblastic large B-cell non-Hodgkin
Area of Science:
- Oncology
- Dermatology
- Pathology
Background:
- Secondary skin involvement in lymphoma typically presents non-specifically in advanced stages.
- Cutaneous manifestations of lymphoma can sometimes mimic other inflammatory conditions, complicating diagnosis.
Observation:
- A patient presented with an inflammatory pericicatricial patch mimicking cellulitis post-cervical laminectomy.
- Initial investigations, including blood cultures and skin biopsy, were negative for infection.
- Subsequent development of subcutaneous nodules and histological analysis confirmed diffuse immunoblastic large B-cell non-Hodgkin's lymphoma.
Findings:
- Histological and immunolabelling confirmed a specific clone of B lymphocytes.
- The lymphoma infiltrated the soft subcutaneous areas and lymph nodes.
- Complete regression of lesions was achieved with CHOP-rituximab polychemotherapy.
Implications:
- This case highlights that specific lymphoid infiltration in cutaneous lymphoma can present atypically, resembling inflammatory conditions.
- Histological analysis is crucial for definitive diagnosis of unusual lymphoma presentations.
- The pericicatricial location may suggest a role for cutaneous aggression or local invasion in lymphoma development.
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