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Related Experiment Video

Updated: Jun 27, 2026

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis

Published on: February 9, 2021

Alkaptonuria presenting with ochronotic spondyloarthropathy.

R Al-Mahfoudh¹, S Clark, N Buxton

¹Department of Neurosurgery, Walton Centre, Liverpool, UK.

British Journal of Neurosurgery

|December 17, 2008

Summary

Alkaptonuria, a rare metabolic disorder, causes homogentisic acid buildup. This case highlights ochronotic spondyloarthropathy in a 58-year-old woman, emphasizing characteristic imaging findings and reviewing management strategies.

Related Experiment Videos

Last Updated: Jun 27, 2026

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis

Published on: February 9, 2021

Area of Science:

Metabolic disorders
Genetics
Rheumatology

Background:

Alkaptonuria is a rare autosomal recessive metabolic disease characterized by homogentisic acid deposition.
Ochronotic arthropathy, the joint manifestation of alkaptonuria, commonly presents as severe spondyloarthropathy.
Early diagnosis and management are crucial for patients with alkaptonuria.

Observation:

A 58-year-old woman presented with persistent back pain.
Radiographic and MRI findings were consistent with ochronotic spondyloarthropathy.
The patient's clinical presentation and diagnostic imaging were analyzed.

Findings:

The case confirms the characteristic radiographic and MRI features of ochronotic spondyloarthropathy.
Homogentisic acid deposition was identified as the underlying cause.
The patient's symptoms and diagnostic results align with established literature.

Implications:

This case underscores the importance of recognizing ochronotic spondyloarthropathy in patients with unexplained back pain.
Understanding the imaging characteristics aids in early diagnosis of alkaptonuria.
Reviewing management strategies is essential for improving patient outcomes in alkaptonuria.