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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma

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Updated: Jun 27, 2026

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation
08:44

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Published on: May 30, 2020

Sex differences in asthma.

Jennifer W McCallister1, John G Mastronarde

  • 1Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, The Ohio State University Medical Center, Columbus, Ohio 43210, USA. Jennifer.McCallister@osumc.edu

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
|December 17, 2008
PubMed
Summary
This summary is machine-generated.

Men and women experience asthma differently, impacting prevalence and potentially disease progression. This review examines sex-based disparities in asthma and explores hypotheses explaining these differences.

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Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

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Last Updated: Jun 27, 2026

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation
08:44

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Published on: May 30, 2020

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Area of Science:

  • Pulmonology
  • Sex-based medicine
  • Epidemiology

Background:

  • Asthma is a prevalent chronic respiratory condition with significant variations in occurrence based on patient sex and age.
  • Observed differences in asthma presentation and progression between males and females are not consistently reflected in clinical management strategies.
  • Understanding sex-specific asthma characteristics is crucial for advancing personalized patient care.

Purpose of the Study:

  • To comprehensively review and synthesize current knowledge on sex-related differences in asthma.
  • To explore the major hypotheses proposed to explain these observed sex-based disparities in asthma.
  • To highlight the implications of these differences for clinical practice and future research directions.

Main Methods:

  • Literature review of existing research on asthma prevalence, pathophysiology, and clinical presentation.
  • Analysis of studies investigating sex-specific factors influencing asthma development and exacerbations.
  • Synthesis of hypotheses related to hormonal, genetic, and environmental influences on sex differences in asthma.

Main Results:

  • Significant sex-based variations exist in asthma prevalence, symptom severity, and response to treatment.
  • Hormonal fluctuations, genetic predispositions, and differing environmental exposures are implicated as key factors contributing to these differences.
  • Current clinical guidelines may not adequately address the nuanced sex-specific aspects of asthma management.

Conclusions:

  • Sex is a critical determinant of asthma epidemiology and clinical phenotype, necessitating tailored approaches.
  • Further research is warranted to elucidate the precise mechanisms underlying sex differences in asthma.
  • Integrating sex as a biological variable into asthma research and clinical practice can improve patient outcomes.