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[Composition and property characterization of Rhizoma Dioscoreae polysaccharide-Fe (III) complex]
Ming-jing Li1, Jing Yang, Ning Wang
1Key Lab of Natural Drug and Immune Engineering, College of Chemistry and Chemical Engineering Henan University, Kaifeng 475001, China.
Summary
Rhizoma Dioscoreae polysaccharide-Fe (III) complex (RDPC) is a stable, water-soluble compound. This novel iron complex shows potential as a new iron supplement due to its stability at physiological pH.
Area of Science:
- Biochemistry
- Materials Science
Context:
- Iron deficiency anemia is a prevalent global health issue.
- Traditional iron supplements can cause gastrointestinal side effects.
- Development of novel, stable iron delivery systems is crucial.
Purpose:
- To characterize the physicochemical properties and composition of Rhizoma Dioscoreae polysaccharide-Fe (III) complex (RDPC).
- To evaluate the stability of RDPC under various conditions.
- To determine the iron and polysaccharide content in RDPC.
Summary:
- RDPC was synthesized and characterized as a brownish-red, water-soluble powder.
- Spectroscopic and microscopic analyses revealed RDPC as a surface complex with polysaccharide bound to a beta-FeOOH core.
- RDPC demonstrated excellent stability in aqueous solutions across a wide pH range (3.8-11.6).
- Iron content was approximately 17%, and polysaccharide content was 16.27%.
Impact:
- This study reports the first characterization of RDPC.
- RDPC exhibits stability under physiological pH, suggesting suitability for oral administration.
- RDPC represents a promising new candidate for iron supplementation therapy.
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