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High-plex Imaging using Spectral Confocal Microscopy to Minimize Non-specific Tissue Fluorescence
Published on: October 28, 2025
[Observation of ultrastructure and ECP expression in nasal polyps]
Zhongfang Xia1, Weijia Kong, Jianxin Yue
1Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Summary
Eosinophilic inflammation and eosinophil cationic protein (ECP) are implicated in chronic rhinosinusitis with nasal polyps (CRSwNP). These findings highlight their role in CRSwNP pathogenesis.
Area of Science:
- Otorhinolaryngology
- Pathology
- Immunology
Context:
- Chronic rhinosinusitis with nasal polyps (CRSwNP) is a complex inflammatory condition.
- The role of eosinophils and their mediators in CRSwNP pathogenesis requires further elucidation.
Purpose:
- To investigate the ultrastructural characteristics of nasal polyps.
- To examine the expression of eosinophil cationic protein (ECP) in CRSwNP.
Summary:
- Electron microscopy revealed increased eosinophils with degranulation and cavitation in CRSwNP patients.
- In situ hybridization showed up-regulated ECP mRNA expression in nasal polyps.
- These findings suggest eosinophilic infiltration and ECP-mediated inflammation are involved in CRSwNP.
Impact:
- Provides insights into the cellular mechanisms underlying CRSwNP.
- May inform future therapeutic strategies targeting eosinophilic inflammation in CRSwNP.
