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Updated: Jun 27, 2026

Ole Isacson: Development of New Therapies for Parkinson's Disease
Published on: April 29, 2007
What's in the pipeline for the treatment of Parkinson's disease?
1Movement Disorders Center, Duke University Medical Center, DUMC Box 3333, Durham, NC 27710, USA. david.sommer@duke.edu
Abstract:
Parkinson's disease (PD) is a common, debilitating neurodegenerative disorder that creates a significant burden for patients, family members and society at large. Major unmet needs include effective therapies that could favorably modify the underlying pathogenetic processes in PD, and better control of motor and nonmotor symptoms in advanced-stage disease. This review examines the current state of development of potential PD therapies, including dopaminergic therapies, modulators of adenosine and glutamate receptors, cell-based therapies, genetic therapies and device-based therapies. In addition, research into potential neuroprotective agents and pipeline therapies for nonmotor symptoms of PD are summarized.
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