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Published on: August 4, 2021
The association of Apoprotein E polymorphisms with recurrent pregnancy loss
Chelsi Goodman1, Cyle S Goodman, Jee Hur
1CARI Reproductive Institute, Chicago, IL, USA.
Apolipoprotein E4 (Apo E4) genotype is more prevalent in women with recurrent pregnancy loss, suggesting it may be a risk factor for thrombophilia and pregnancy complications.
Area of Science:
- Genetics
- Reproductive Medicine
- Thrombosis Research
Background:
- Recurrent pregnancy loss (RPL) is linked to thrombogenic gene polymorphisms.
- Apolipoprotein E (Apo E) influences lipid metabolism during pregnancy.
- The Apo E4 allele is associated with an increased risk of thrombosis.
Purpose of the Study:
- To investigate the frequency of the Apo E4 genotype in women with RPL.
- To determine if Apo E4 is a risk factor for RPL.
Main Methods:
- DNA was extracted from buccal swabs of 69 women with RPL and 37 controls.
- Polymerase Chain Reaction (PCR) was used to amplify Apo E2, E3, and E4 alleles.
Main Results:
- Apo E3/4 and E4/4 genotypes were found in 21.7% of women with RPL.
- This prevalence was significantly higher than in control women (5.4%, P = 0.036).
Conclusions:
- Apo E4 polymorphism may contribute to thrombophilic risk factors in RPL.
- This finding highlights a potential genetic predisposition to RPL.
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