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Published on: June 21, 2021
The influence of diet on protein oxidation
1Pharmaceutical Sciences Research Institute, Aston University, Aston Triangle, Birmingham B4 7ET, UK. h.r.griffiths@aston.ac.uk
Nutrition Research Reviews
|December 18, 2008
Summary
Dietary antioxidants may preserve protein function by mitigating oxidative stress. This study evaluates evidence on how diet impacts protein oxidation, crucial for health and aging-related diseases.
Area of Science:
- Biochemistry
- Molecular Biology
- Nutrition Science
Background:
- Protein oxidation, involving cysteine thiol groups, regulates cellular signaling and gene expression.
- While transient modifications are essential, sustained oxidative stress causes irreversible protein damage, linked to aging diseases.
- Dietary factors may influence the balance of protein oxidation, potentially offering health benefits.
Purpose of the Study:
- To evaluate current in vivo evidence on the effects of dietary antioxidants and oxidants on protein oxidation.
- To highlight areas for future research regarding diet and protein oxidation.
Main Methods:
- Review of in vivo studies examining dietary antioxidant and oxidant impacts.
- Analysis of evidence linking protein oxidation to disease and aging.
Main Results:
- Protein oxidation plays a dual role: essential for signaling and a cytotoxic hazard.
- Dietary interventions may modulate protein oxidation states.
- Further research is needed to fully understand diet's influence on protein function.
Conclusions:
- Dietary intake of antioxidants and oxidants can influence protein oxidation levels.
- Understanding these dietary effects is crucial for preserving protein function and potentially mitigating age-related diseases.
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