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Updated: Jun 27, 2026
Optimization of Breast Biopsy and Mastectomy Sample Collection Procedures for Biobanking, Personalized Medicine, and Research Applications
Published on: September 2, 2025
[Management of non-malignant results in core needle biopsy of breast lesions]
Zhao-Qing Fan1, Tao Ouyang, Jin-Feng Li
1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Breast Cancer Center, Peking University School of Oncology, Beijing Cancer Hospital, Beijing 100142, China. zhqfan@sina.com
Objective:
To study the strategy of management of non-malignant results in core needle biopsy (CNB) of breast lesions.
Methods:
Consecutive 2654 breast lesions underwent CNB with 14-gauge automated needles. 1130 lesions with diagnosis of non-malignant breast lesions examined by CNB were followed up. The histological diagnosis of CNB, subsequent excision or repeat CNB, and the follow-up for cases without repeat biopsy were studied.
Results:
Among the 1130 non-malignant breast lesions examined by CNB, 530 underwent re-biopsy and 73 cases of carcinoma were found. 491 lesions were followed up for 1 - 38 months (median, 13.3 months) and another 4 cases of carcinoma were found during the follow-up. 109 cases were lost to follow-up. 57.9% (22/38) of the atypical ductal hyperplasia, 22.2% (4/18) of the atypical ductal cells, 27.9% (24/86) of the papillary lesions, and 90.0% (9/10) of the suspicious carcinoma diagnosed by CNB were re-diagnosed as breast cancer finally.
Conclusions:
Repeat biopsy is required for the high-risk lesions diagnosed by breast CNB. Excision can be avoided on the benign lesions whose CNB diagnosis is consistent with those by physical examination and imaging.
