Related Experiment Video
Updated: Jun 5, 2026
05:56
Phase-Resolved Functional Lung MRI for Pulmonary Ventilation and Perfusion (V/Q) Assessment
Published on: August 9, 2024
Association between Impaired Lung Function and Pulmonary Perfusion Defects Assessed by Phase-resolved Functional Lung
Tao Ouyang1,2,3,4, Qiming Liu1,3,4, Andreas Voskrebenzev5,6
1Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
Radiology. Cardiothoracic Imaging
|June 4, 2026
Summary
Impaired lung function, including preserved ratio impaired spirometry (PRISm), restrictive physiology (RP), and airflow obstruction (AO), is linked to increased pulmonary perfusion defects (QDP) detected by phase-resolved functional lung (PREFUL) MRI.
Area of Science:
- Radiology and Imaging
- Pulmonary Medicine
- Medical Diagnostics
Background:
- Lung function impairment affects a significant portion of the population.
- Pulmonary perfusion defects can indicate underlying respiratory disease.
- Phase-resolved functional lung (PREFUL) MRI offers a method to assess lung perfusion.
Purpose of the Study:
- To investigate the association between various types of impaired lung function and pulmonary perfusion defect percentage (QDP).
- To utilize PREFUL MRI to quantify perfusion defects in relation to spirometry results.
- To explore potential nonlinear relationships between lung function and perfusion defects.
Main Methods:
- Prospective study involving 287 participants.
- Spirometry to classify lung function (normal, PRISm, RP, AO).
- PREFUL MRI for ventilation/perfusion assessment and CT for emphysema evaluation.
- Linear regression and restricted cubic spline (RCS) analyses were performed.
Main Results:
- All categories of impaired lung function (PRISm, RP, AO) were significantly associated with higher QDP.
- Lower FEV1% predicted, FVC% predicted, FEV1/FVC ratio, and higher emphysema percentage correlated with increased QDP.
- Nonlinear associations were observed between pulmonary function indicators and QDP, with significant interactions in subgroup analyses.
Conclusions:
- Impaired lung function is significantly associated with increased pulmonary perfusion defects.
- PREFUL MRI is a valuable tool for detecting and quantifying perfusion abnormalities in patients with lung function impairment.
- Findings highlight the link between spirometric abnormalities and perfusion deficits, underscoring the utility of advanced MRI techniques in respiratory assessment.
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