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Measuring Lactase Enzymatic Activity in the Teaching Lab
Published on: August 6, 2018
Urinary D-lactate excretion in infants receiving Lactobacillus johnsonii with formula
Elisabeth Haschke-Becher1, Oscar Brunser, Sylvia Cruchet
1Central Laboratory, University Hospital of Neurology, Paracelsus Medical University, Salzburg, Austria. e.haschke-becher@salk.at
Annals of Nutrition & Metabolism
|December 18, 2008
Summary
Formula supplemented with Lactobacillus johnsonii (La1) did not increase D-lactate excretion in infants. This suggests no heightened risk of D-lactic acidosis from La1-containing infant formula.
Area of Science:
- Probiotics and Gut Microbiome
- Infant Nutrition
- Metabolic Health
Background:
- Probiotic supplementation may enhance gut flora and immunity.
- Potential adverse effects, like D-lactate accumulation, require investigation.
- Lactobacillus johnsonii (La1) is a probiotic used in infant formulas.
Purpose of the Study:
- To evaluate the risk of D-lactate accumulation and metabolic acidosis in infants fed formula with Lactobacillus johnsonii (La1).
Main Methods:
- A double-blind, randomized controlled trial involved 71 infants (4-5 months old).
- Urinary D- and L-lactate excretion was measured before and after 4 weeks of feeding with La1-supplemented formula, control formula, or breast milk.
- Excretion was normalized to urinary creatinine levels.
Main Results:
- No baseline differences in lactate excretion were observed among groups.
- After 4 weeks, D-lactate excretion was similar between formula groups but higher than in breastfed infants.
- Urinary D-lactate levels in infants receiving La1 remained within normal ranges for healthy infants.
Conclusions:
- Supplementing infant formula with Lactobacillus johnsonii (La1) does not alter urinary lactate excretion.
- There is no evidence of an increased risk of D-lactic acidosis associated with La1 supplementation in infant formula.
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