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Updated: Jun 27, 2026

Imaging Initial Ca2+ Microdomains in Primary T Cells

Imaging Initial Ca²⁺ Microdomains in Primary T Cells

Published on: October 4, 2024

Calcium signaling in immune cells.

Monika Vig¹, Jean-Pierre Kinet

¹Laboratory of Allergy and Immunology, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA. mvig@bidmc.harvard.edu

Nature Immunology

|December 18, 2008

Summary

Calcium signaling is crucial in lymphocytes, with store-operated calcium (SOC) channels mediating calcium influx. Recent discoveries of CRACM1 and STIM1 advance understanding of this vital pathway.

Area of Science:

Immunology
Cell Biology
Biochemistry

Background:

Calcium ions (Ca2+) function as critical second messengers in diverse cell types, including lymphocytes.
Lymphocytes maintain a low intracellular Ca2+ concentration at rest.
Antigen receptor engagement triggers Ca2+ influx into lymphocytes via multiple pathways.

Purpose of the Study:

To review recent advancements in understanding calcium (Ca2+) signaling in lymphocytes.
To emphasize the role and mechanisms of store-operated calcium (SOC) channels in lymphocyte activation.
To identify current challenges and future research directions in the field.

Main Methods:

Literature review focusing on calcium signaling and SOC channels in lymphocytes.
Discussion of molecular components like CRACM1 and STIM1.

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Analysis of genetic and molecular manipulation studies.

Main Results:

Store-operated calcium (SOC) channels are a primary route for Ca2+ entry in lymphocytes.
The identification of CRACM1 (pore subunit) and STIM1 (calcium sensor) has enabled detailed study of SOC entry.
Advances in understanding the molecular basis of SOC channel function.

Conclusions:

Significant progress has been made in elucidating Ca2+ signaling pathways in lymphocytes, particularly SOC entry.
The molecular players CRACM1 and STIM1 are central to SOC channel function.
Further research is needed to fully address outstanding questions and explore future therapeutic avenues.