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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...

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Induced Pluripotent Stem Cell Generation from Blood Cells Using Sendai Virus and Centrifugation
09:57

Induced Pluripotent Stem Cell Generation from Blood Cells Using Sendai Virus and Centrifugation

Published on: December 21, 2016

Stem cell sources for regenerative medicine.

Ali M Riazi1, Sarah Y Kwon, William L Stanford

  • 1Department of Chemical Engineering, University of Toronto, Toronto, Ontario, Canada.

Methods in Molecular Biology (Clifton, N.J.)
|December 18, 2008
PubMed
Summary
This summary is machine-generated.

Tissue-resident stem cells are crucial for organ health. Advances in stem cell therapies offer regenerative medicine potential, but technical and social challenges remain for clinical application.

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Area of Science:

  • Stem Cell Biology
  • Regenerative Medicine
  • Tissue Homeostasis

Background:

  • Tissue-resident stem cells are vital for maintaining organ system homeostasis.
  • Recent advancements in stem cell isolation and culture techniques are accelerating research.
  • The field of regenerative medicine holds significant therapeutic promise.

Purpose of the Study:

  • To review the current progress in therapeutic applications of various stem cells.
  • To discuss the technical and social challenges hindering the realization of stem cell therapy potential.

Main Methods:

  • Literature review of current stem cell research.
  • Analysis of methodologies for stem cell isolation and culture.
  • Discussion of clinical and preclinical trial progress.

Main Results:

  • Overview of diverse stem cell applications in preclinical and clinical settings.
  • Identification of key technical challenges in stem cell therapy development.
  • Highlighting of significant social and ethical considerations.

Conclusions:

  • Stem cell therapies are advancing rapidly, offering new hope for regenerative medicine.
  • Overcoming technical and societal hurdles is essential for widespread clinical adoption.
  • Continued research and ethical discourse are critical for realizing the full potential of stem cells.