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Related Concept Videos

Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Modified-Release Drug Delivery Systems: Classification01:23

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Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...

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Published on: September 2, 2009

Local drug delivery with a self-contained, programmable, microfluidic system.

J Fiering1, M J Mescher, E E Leary Swan

  • 1Charles Stark Draper Laboratory, Cambridge, MA, USA. jfiering@draper.com

Biomedical Microdevices
|December 18, 2008
PubMed
Summary
This summary is machine-generated.

This study presents a novel wearable drug delivery system for long-term, localized therapy. The device offers programmable, variable dosing and enables remote adjustments for chronic conditions.

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Area of Science:

  • Biomedical Engineering
  • Drug Delivery Systems
  • Pharmacology

Background:

  • Current chronic drug delivery methods lack localized control, in situ adjustability, and wearable configurations for clinical trials.
  • Limitations include inability to target specific organs, modify delivery rates remotely, or function in untethered settings.

Purpose of the Study:

  • To develop and optimize a small, self-contained system for long-term, localized liquid-phase drug delivery.
  • To enable remote programming and modification of infusion rates for controlled, variable dosing.

Main Methods:

  • Integration of a commercial miniature pump with microfabricated components for ultralow flow rates and small pulse volumes (as low as 370 nL).
  • Development of a system capable of infusing and immediately withdrawing liquid, achieving zero net volume transfer for compound exchange.
  • In vitro and in vivo testing, including a guinea pig otology model.

Main Results:

  • Demonstrated in vitro repeatability of delivered pulse volume for nearly 3 months.
  • Successfully achieved localized and reversible changes in auditory sensitivity in vivo by infusing a glutamate receptor antagonist into the cochlea.

Conclusions:

  • The developed system offers a promising solution for long-term, localized drug delivery with precise, remotely controlled dosing.
  • The technology has potential applications in clinical trials and managing chronic conditions requiring targeted therapies.