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Updated: Jun 27, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
Creating a culture of thoughtful prescribing
Kari L Franson1, Eline A Dubois, Marieke L de Kam
1Centre for Human Drug Research, Zernikedreef 10, Leiden, The Netherlands. kfranson@chdr.nl
Structured training improves physician communication of therapeutic plans. The Individualized Therapy Evaluation and Plan (ITEP) method enhanced student performance in complex cases with practice.
Area of Science:
- Medical Education
- Clinical Communication
- Health Professions Training
Background:
- Poor communication among healthcare professionals affects 170,000 Dutch patients annually, leading to inappropriate therapy in 44% of cases.
- Physician training in communicating therapeutic content often lacks structure, contributing to these communication breakdowns.
Purpose of the Study:
- Introduce a structured format for creating and communicating therapeutic plans.
- Offer students opportunities for practice and feedback on therapeutic planning and communication skills.
Main Methods:
- Developed the Individualized Therapy Evaluation and Plan (ITEP) framework for decision-making and communication.
- Assessed student therapeutic plans using a 15-point criteria form for simple and complex cases.
- Tracked improvements in complex case scores over three years with increased ITEP practice.
Main Results:
- In 2003, 82% of students succeeded with simple cases, but only 32% with complex cases.
- Subsequent years showed significant improvement in complex case scores, rising from an average of 3.8 to 6.8.
- Increased practice with the ITEP method correlated with better performance on complex therapeutic plans.
Conclusions:
- Medical students can manage simple drug regimens but require structured practice, like the ITEP, for complex cases involving multiple disease states.
- The ITEP framework demonstrates potential for enhancing therapeutic communication skills in medical education.
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